| 5-卤代-2-(4-芳基-噻唑-2-基)-腙甲基-苯酚的合成 |
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| 引用本文： | 汤仁和,盛夏鑫,吕梦飞,陈定奔. 5-卤代-2-(4-芳基-噻唑-2-基)-腙甲基-苯酚的合成[J]. 当代化工, 2017, 46(5). DOI: 10.3969/j.issn.1671-0460.2017.05.001 |
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| 作者姓名： | 汤仁和 盛夏鑫 吕梦飞 陈定奔 |
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| 作者单位： | 台州学院医药化工学院,浙江台州,318000 |
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| 基金项目： | 国家自然科学基金项目;项目号:21302135 |
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| 摘 要： | 以5-卤代-水杨醛为原料,与氨基硫脲发生缩合反应,生成5-卤代-水杨醛缩氨基硫脲。然后分别与ω-溴代苯乙酮、对甲氧基-ω-溴代苯乙酮在甲醇或丙酮溶剂中回流反应10 min,得到6个5-卤代-2-(4-芳基-噻唑-2-基)-腙甲基-苯酚,最后通过红外、核磁、质谱对其进行了结构表征。
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| 关 键 词： | 噻唑类化合物 5-卤代-2-(4-芳基-噻唑-2-基)-腙甲基-苯酚 合成 |
Synthesis of 5-Halogenated-2-(4-aryl-thiazole-2-radical)-phenol-methyl Hydrazone |
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| TANG Ren-he,SHENG Xia-xin,LV Meng-fei,CHEN Ding-ben. Synthesis of 5-Halogenated-2-(4-aryl-thiazole-2-radical)-phenol-methyl Hydrazone[J]. Contemporary Chemical Industry, 2017, 46(5). DOI: 10.3969/j.issn.1671-0460.2017.05.001 |
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| Authors: | TANG Ren-he SHENG Xia-xin LV Meng-fei CHEN Ding-ben |
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| Abstract: | In this experiment,5-halogenated salicylaldehyde thiosemicarbazone (Ⅰ) was prepared by the condensation reaction between 5-halogenated salicylaldehyde and thiosemicarbazide.Then,the reflux reaction between 5-halogenated salicylaldehyde thiosemicarbazone (Ⅰ) and 2-bromo-1-phenylethanone or 2-bromo-1-(4-methoxyphenyl) ethanone was carried out for 10 min to gain 5-halogenated-2-(4-aryl-thiazole-2-radical)-phenol-methyl hydrazone.All products were characterized by IR,NMR,and mass spectrometry. |
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| Keywords: | Thiazole 5-halogenated-2-(4-aryl-thiazole-2-)-phenol-methyl hydrazone Synthesis |
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