Human leucocytic antigens (HLA) in breast cancer |
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| Authors: | BM Biswal R Kumar PK Julka U Sharma MC Vaidya |
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| Affiliation: | Radiotherapy Dept, All India Institute of Medical Sciences, Ansari Nagar, New Delhi. |
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| Abstract: | HLA frequencies of fifty (50) female breast cancer patients were compared with 200 age matched female controls. A total of 20 HLA-A locus, 35 HLA-B locus and 8 HLA-C locus antigens were studied. The HLA-A2, A11, Aw19 and A30; HLA-B8, B14 and HLA Cw6 were found significantly higher than the controls. The HLA-A11, HLA-Aw19 and HLA-B8 were found protective whereas, HLA-A2, HLA-B14 and HLA-Cw6 were a risk for breast cancer. The prective antigens' probable involvement through immunogenic mechanism in breast cancer is emphasized in this article. |
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