Reduction of fatty acid hydroperoxides by human parotid saliva |
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| Authors: | Junji Terao Akihiko Nagao Hiroko Yuki Yoshio Itoh |
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| Affiliation: | (1) National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 305 Tsukuba, Ibaraki;(2) Lotte Central Laboratory Co., Ltd., 336 Urawa, Saitama, Japan |
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| Abstract: | Arachidonic acid hydroperoxide (15-hydroperoxyeicosatetraenoic acid; 15-HPETE) was introduced into human parotid saliva and incubated at 37°C. Straight phase high-performance liquid chromatography analysis of the reaction mixture showed that 15-HPETE was detoxified to its reduced form, 15-hydroxyeicosatetraenoic acid, in the presence of glutathione. Therefore, it is concluded that human parotid saliva possesses fatty acid hydroperoxide-reducing ability. However, its effectiveness was found to be lower than that of blood plasma. |
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