| 2-甲基-苯并咪唑-5-羧酸的合成与表征 |
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| 引用本文： | 伍国云.2-甲基-苯并咪唑-5-羧酸的合成与表征[J].广东化工,2014(2):42-43. |
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| 作者姓名： | 伍国云 |
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| 作者单位： | 湖南食品药品职业学院,湖南长沙410208 |
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| 摘 要： | 文章以3,4-二氨基苯甲酸和乙酸为主要原料,合成了2-甲基-苯并咪唑-5-羧酸,并探讨了反应温度、反应物料摩尔比以及反应时间对目标产物的影响。通过红外、熔点、元素分析等方法对产物进行了表征。得到合成2-甲基-苯并咪唑-5-羧酸的最佳条件为以4 mol/L HCl溶液作为溶剂,同时作为催化剂,反应温度为140℃,反应时间14 h,3,4-二氨基苯甲酸与乙酸的最佳摩尔比为1∶5,反应条件温和,产物收率达到75%。
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| 关 键 词： | -甲基-苯并咪唑--羧酸 -二氨基苯甲酸 乙酸 |
Preparation and Characterization of 2-methyl- Benzimidazole-5-carboxylic Acid |
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| Wu Guoyun.Preparation and Characterization of 2-methyl- Benzimidazole-5-carboxylic Acid[J].Guangdong Chemical Industry,2014(2):42-43. |
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| Authors: | Wu Guoyun |
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| Affiliation: | Wu Guoyun (HuNan Food and Drug Vocational College, Changsha 410208, China) |
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| Abstract: | The 2-methyl- benzimidazole - 5 - carboxylic acid was prepared by using 3,4 - diamino-benzoic acid and acetic acid as main materials. The product was characterized by FT-IR,melting point, elemental analysis. Its reaction conditions were researched,the results showed that optimal reaction conditions ： 4 mol/L HCI as solution and catalyst, the reaction temperature was 140 ℃, the reaction time 14 h, 3,4 - diamino-benzoic acid and acetic acid of the best molar ratio of 1 ： 5, the yield can reach 75 %. |
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| Keywords: | 2-methyl- benzimidazole - 5-carboxylic acid： 3 4 - diamino-benzoic acid： acetic acid |
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