| 蛋氨酸羟基类似物对小鼠组织自由基和抗氧化作用研究 |
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| 引用本文： | 杨永兰,夏淑芳,刘骥,乐国伟,施用晖. 蛋氨酸羟基类似物对小鼠组织自由基和抗氧化作用研究[J]. 食品工业科技, 2011, 0(9): 399-402,453 |
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| 作者姓名： | 杨永兰 夏淑芳 刘骥 乐国伟 施用晖 |
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| 作者单位： | 1. 江南大学食品学院==食品营养与功能因子研究中心,江苏无锡,214122
2. 江南大学食品学院,食品营养与功能因子研究中心,江苏无锡214122／江南大学食品科学与技术国家重点实验室,江苏无锡214122 |
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| 基金项目： | 国家自然科学基金(30571347) |
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| 摘 要： | 目的：研究蛋氨酸（MET）和蛋氨酸羟基类似物（HMTBA）对饲喂高脂日粮小鼠自由基水平、抗氧化作用及其血脂代谢的影响。方法：50只昆明种雄性小鼠分成5组,分别是正常＋0.2%MET组、正常＋0.1%MET＋0.1%HMTBA组、高脂＋0.2%MET组、高脂＋0.2%HMTBA组、高脂＋0.1%MET＋0.1%HMTBA组。结果：与正常＋0.2%MET组相比,高脂＋0.2%MET可导致小鼠氧化应激,升高血液和组织的自由基水平,降低机体抗氧化能力,使血脂水平和动脉粥样硬化指数升高;而高脂＋0.2%HMTBA能显著降低机体自由基水平,增强血清及组织中GSH-Px及CAT活性,显著升高T-AOC水平,显著降低MDA水平,与高脂＋0.2%MET组相比,HDL升高,LDL、TG、TC、AI显著降低。结论：两种蛋氨酸源中,HMTBA有较好地抗氧化作用,能够更好地清除体内的自由基,提高机体的抗氧化能力,降低血脂。
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| 关 键 词： | 蛋氨酸 蛋氨酸羟基类似物 高脂日粮 抗氧化作用 降血脂 |
Research of 2-hydroxy-4-(methylthio)butanoic acid on free radicals of tissues and antioxidation of mice |
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| YANG Yong-lan,XIA Shu-fang,LIU Ji,LE Guo-wei,,SHI Yong-hui. Research of 2-hydroxy-4-(methylthio)butanoic acid on free radicals of tissues and antioxidation of mice[J]. Science and Technology of Food Industry, 2011, 0(9): 399-402,453 |
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| Authors: | YANG Yong-lan XIA Shu-fang LIU Ji LE Guo-wei SHI Yong-hui |
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| Affiliation: | YANG Yong-lan1,XIA Shu-fang1,LIU Ji1,LE Guo-wei1,2,SHI Yong-hui1,2(1. Jiangnan University,School of Food Science and Technology,The Research Center of Food Nutrition and Functional Factors,Wuxi 214122,China,2. The State Key Laboratory of Food Science and Technology,Jiangnan University,China) |
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| Abstract: | Objective:To research the effects of methionine sources methionine(MET)and 2-hydroxy-4-(methythio)butanoic acid(HMTBA)on the level of free radicals and antioxidation in mice fed with high-fat diet.Method:Fifty mice were randomly divided into 5 groups:low-fat with 0.2% MET group,low-fat with 0.1% HMTBA and 0.1%MET group,high-fat with 0.2% MET group,high-fat with 0.2% HMTBA group,high-fat with 0.1% HMTBA and 0.1% MET group.Results:Compared with low-fat with 0.2% MET group,high-fat with 0.2% MET group can indu... |
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| Keywords: | methionine 2-hydroxy-4-(methythio)butanoic acid high-fat diet antioxidation lipid lowering |
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