Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study |
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| Authors: | Ingeborg M Kooter A John F Boere Paul HB Fokkens Daan LAC Leseman Jan AMA Dormans Flemming R Cassee |
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| Affiliation: | (1) Centre for Environmental Health Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands;(2) Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands |
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| Abstract: | Background Many epidemiological studies have shown that mass concentrations of ambient particulate matter (PM) are associated with adverse
health effects in the human population. Since PM is still a very crude measure, this experimental study has explored the role
of two distinct size fractions: ultrafine (<0.15 μm) and fine (0.15- 2.5 μm) PM. In a series of 2-day inhalation studies,
spontaneously hypersensitive (SH) rats were exposed to fine, concentrated, ambient PM (fCAP) at a city background location
or a combination of ultrafine and fine (u+fCAP) PM at a location dominated by traffic. We examined the effect on inflammation
and both pathological and haematological indicators as markers of pulmonary and cardiovascular injury. Exposure concentrations
ranged from 399 μg/m3 to 3613 μg/m3 for fCAP and from 269μg/m3 to 556 μg/m3 for u+fCAP. |
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