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| 反相高效液相色谱法测定盐酸米诺环素原位凝胶中盐酸米诺环素的含量 | |
| 引用本文： | 杨跃辉,郜琪臻,丁平田. 反相高效液相色谱法测定盐酸米诺环素原位凝胶中盐酸米诺环素的含量[J]. 化学与生物工程, 2011, 28(2): 92-94. DOI: 10.3969/j.issn.1672-5425.2011.02.028 |
| 作者姓名： | 杨跃辉 郜琪臻 丁平田 |
| 作者单位： | 1. 中国医科大学附属盛京医院药学部,辽宁,沈阳,110004 2. 中国医科大学附属第一医院药学部,辽宁,沈阳,110001 3. 沈阳药科大学药学院,辽宁,沈阳,110015 |
| 摘 要： | 以乙酸铵缓冲盐溶液-乙腈(250;105)为流动相,进样量为10μL,在350 nm处用反相高效液相色谱(RP-HPLC)法测定盐酸米诺环素原位凝胶中盐酸米诺环素的含量.结果表明,盐酸米诺环素浓度在50～1000μg·mL-1(以米诺环素计)范围内与峰面积呈良好的线性关系.该法操作简便,结果准确可靠. |
| 关 键 词： | 盐酸米诺环素 原位凝胶 反相高效液相色谱 |
Determination of Content of Minocycline Hydrochloride in Minocycline Hydrochloride in situ Gels by RP-HPLC |
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| YANG Yue-hui,GAO Qi-zhen,DING Ping-tian. Determination of Content of Minocycline Hydrochloride in Minocycline Hydrochloride in situ Gels by RP-HPLC[J]. Chemistry & Bioengineering, 2011, 28(2): 92-94. DOI: 10.3969/j.issn.1672-5425.2011.02.028 | |
| Authors: | YANG Yue-hui GAO Qi-zhen DING Ping-tian |
| Affiliation: | YANG Yue-hui1,GAO Qi-zhen2,DING Ping-tian3(1.Department of Pharmacy,Shengjing Hospital Affiliated China Medical University,Shenyang 110004,China,2.Department of Pharmacy,The First Hospital Affiliated China Medical University,Shenyang 110001,3.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015,China) |
| Abstract: | A RP-HPLC method for determining minocycline hydrochloride content in minocycline hydrochloride in situ gels was established.Mobile phase was ammonium acetate buffer salt-acetonitrile(250∶105).The injection volume was 10 μL and the detection wavelength was 350 nm.There was a good linear relationship within the range of 50～1000 μg·mL-1 of minocycline hydrochloride.The RP-HPLC method was simple,accurate and reliable. |
| Keywords: | minocycline hydrochloride in situ gels RP-HPLC |
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