Antimicrobial power of biosynthesized Ag nanoparticles using refined Ginkgo biloba leaf extracts |
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Authors: | Wenbo ZHUANG Dafeng HU Xudong ZHANG Kai XIONG Xiao DING Jian LU Yong MAO Peng YANG Chao LIU Yanfen WAN |
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Affiliation: | 1. National Center for International Research on Photoelectric and Energy Materials, Advanced Computing Center, Materials Genome Institute, School of Materials and Energy, Yunnan University, Kunming 650091, China2. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China3. Department of Nuclear Medicine, Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China |
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Abstract: | Silver nanoparticles (Ag NPs), relative to existing antibacterial agents, are more effective, less toxic and more economical, and have shown enormous potential for the nanomedicine application. In this work, we report a ‘green’ method for the rapid and efficient synthesis of Ag NPs using Ginkgo biloba extracts as reducing agent and capping agent. The properties of Ag NPs against fungi and bacteria were investigated. The results showed that the Ginkgo biloba extracts are crucial for the preparation of uniform and monodispersed Ag NPs. The prepared Ag NPs exhibited remarkable antibacterial activities. The minimum inhibitory concentrations of Ag NPs for Escherichia coli and Pseudomonas aeruginosa were 0.044 and 0.088 μg·mL?1, respectively. Moreover, Ag NPs exhibited excellent bactericidal performance against MDR-Pseudomonas aeruginosa. It was found that the effect of the antibacterial activity of Ag NPs on Escherichia coli and Staphylococcus aureus was tightly related to the reactive oxygen species accumulation. This research provides guidelines for the efficient green synthesis of Ag NPs and its antibacterial applications. |
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Keywords: | Ginkgo biloba extract silver nanoparticle green synthesis antibacterial application |
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