高粱乌米对小鼠肠道菌群结构的调控作用

本研究将ICR雄性小鼠分为对照组(喂食普通饲料)和乌米组(喂食乌米饲料),分析小鼠喂食高粱乌米后的体重、血清生理生化指标的变化,并利用高通量测序技术分析肠道微生物的多样性、群落组成以及结构的变化.研究结果显示:乌米可以抑制小鼠体重的增长,与对照组相比,可以显著降低血清的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(...

Sphacelotheca sorghi (Link) Clint Regulates the Structure of Gut Microflora in Mice

In this study, ICR male mice were divided into a control group (fed with ordinary diet) and a umi group (fed with umi diet), and analyzed the changes in body weight and serum physio-biochemical indices of the mice fed with Sphacelotheca sorghi (Link) Clint, and use high-throughput sequencing technology to analyze the diversity, community composition and community changes of intestinal microbes. The results of the study showed: Umi could inhibit the weight gain of mice, and could significantly reduce serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) content compared with the control group. The content of lipoprotein (HDL) increased significantly. Umi could also change the intestinal microbial communities of mice. Compared with the control group, the abundance of Actinobacteria and Firmicutes in the intestinal flora of mice in the Umi group increased, while the abundance of Bacteroidetes decreased. At the genus level, Umi could increase the abundance of short-chain fatty acid-producing bacteria such as Acinetobacter, Clostridium, Clostridium XlVa, and Ruminococcus in the intestinal flora of mice, and reduce the abundance of Barnesiella and Lactobacillus. At the species level, the abundance of intestinal microbe Muribaculum intestinale in the Umi group decreased significantly, while the abundance of Kineohrix alysoides increased significantly. In summary, Sphacelotheca sorghi (Link) Clint can effectively control the weight gain of mice, regulate the intestinal microbial communities of mice, and increase the abundance of beneficial bacteria.