馥郁香型白酒对高脂饮食小鼠脂代谢及肠道菌群的影响

为探索馥郁香型白酒对高脂饮食小鼠脂质代谢及肠道菌群的影响，采用高脂饲料构建高脂小鼠模型，通过灌胃不同剂量的馥郁香型白酒，研究小鼠脏器、血脂相关指标和肠道菌群的变化。结果表明，适量饮用馥郁香型白酒能抑制高脂饲料引起的小鼠肝脏、附睾脂肪和肾周脂肪系数的升高及其相关脂质的积累，以及甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的升高，提高肝脏内超氧化物歧化酶（SOD）活力（P＜0.05）。在属水平上，饮酒伴随高脂饮食缓解了高脂饮食引起的脱硫弧菌属（Desulfovibrio）相对含量的上升和罗斯氏菌属（Roseburia）相对含量的下降，显著增加了瘤胃球菌属（Ruminococcus）的相对含量（P＜0.05），说明适量饮用馥郁香型白酒对高脂饮食造成的小鼠脂代谢异常和肠道菌群的失衡有一定的缓解作用。

Effects of Fuyu-flavor Baijiu on the lipid metabolism and intestinal flora in high-fat diet mice

In order to explore the effect of Fuyu-flavor Baijiu (Chinese liquor) on lipid metabolism and intestinal flora of high-fat diet mice, a high-fat mouse model was constructed by high-fat forage. Through intragastric administration of different doses of Fuyu-flavor Baijiu to mice, the changes in the related indicators of organs, blood lipids and the intestinal flora were studied. The results showed that appropriate dosage of Fuyu-flavor Baijiu could effectively inhibit the increase in liver, epididymisadipose and perirenal fat coefficient, the accumulation of related lipids, and the increase in the content of triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and improve the activity of superoxide dismutase (SOD) in the liver of mice caused by high-fat diet (P＜0.05). At the genus level, drinking accompanied by a high-fat diet alleviated the increase in the relative content of Desulfovibrio and the decrease in the relative content of Roseburia caused by the high-fat diet, and significantly increased the relative content of Ruminococcus (P＜0.05), indicating that appropriate drinking Fuyu-flavor Baijiu had a certain alleviating effect on the abnormal lipid metabolism and the imbalance of intestinal flora in mice caused by high-fat diet.