结肠定向吸收增强型递送体系的创建及应用研究进展

结肠定向吸收增强型递送体系是具有突出结肠靶向黏附能力和结肠增强吸收功能的新型结肠靶向递送体系.相较传统结肠靶向递送体系,其优势在于释放位点及作用时间的精准控制、递送体系比表面积的增加以及靶向黏附效果的增强.本文综述了结肠定向吸收增强型递送体系的研究进展和评价方法,并从结肠定向吸收增强型递送体系的类型、结构、制备方法及递...

Recent Progress in the Preparation and Application of Absorption-enhanced Colon-targeted Delivery System

The absorption-enhanced colon-targeted delivery system is a novel colon-targeted delivery system with outstanding colonic adhesion capacity and enhanced colonic absorption function. Compared with the traditional colon-targeted delivery system, it has some advantages such as precisely control of release sites and action time, increased specific surface area and enhanced targeted adhesion efficiency. In this paper, we review the literature on absorption-enhanced colon-targeted delivery systems in terms of their types, structures and preparation methods as well as substances that can be delivered using them, and we summarizes the in vivo and in vitro evaluation methods for absorption-enhanced colon-targeted delivery systems. Moreover, we give an outlook on the current and potential applications of absorption-enhanced colon-targeted delivery systems. Through this review, we conclude that absorption-enhanced colon-targeted delivery systems provide a feasible and innovative method to analyze the mechanism behinds the health benefits of foodborne biocompounds.