| 榛蘑多糖对四氯化碳所致小鼠急性肝损伤的保护作用 |
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| 引用本文： | 崔海丹,王欣彤,赵青,沈明花.榛蘑多糖对四氯化碳所致小鼠急性肝损伤的保护作用[J].食品科技,2011(10):170-172,177. |
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| 作者姓名： | 崔海丹 王欣彤 赵青 沈明花 |
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| 作者单位： | 延边大学药学院;吉林大学药学院; |
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| 基金项目： | 国家自然科学基金项目(30760150/c1506) |
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| 摘 要： | 目的:研究榛蘑多糖对四氯化碳所致小鼠急性肝损伤的保护作用。方法:将50只小鼠按体重分为5组;分别为正常组、四氯化碳模型组、阳性对照组(联苯双酯200mg/kg/d)、榛蘑多糖大小剂量组(200、100mg/kg/d),每组10只。灌胃7d后,腹腔注射0.1%四氯化碳,24h后取血测定血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)活性,取肝测定肝脏丙二醛(MDA)含量以及谷胱甘肽过氧化物酶(GSH-Px)活性和还原型谷胱甘肽(GSH)的含量。结果:榛蘑多糖可显著降低四氯化碳所致急性肝损伤小鼠血清ALT和AST活性(P<0.01或P<0.05),也能明显降低四氯化碳所致急性肝损伤小鼠肝脏MDA含量(P<0.05),升高GSH-Px活性(P<0.01或P<0.05)和GSH的含量(P<0.05)。结论:榛蘑多糖对四氯化碳所致小鼠急性肝损伤具有一定的保护作用。
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| 关 键 词： | 榛蘑多糖 肝损伤 抗氧化 |
Protective effect of Armillariella mellea polysaccharide on liver injury mice induced by CCl4 |
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| CUI Hai-dan,WANG Xin-tong,ZHAO Qin,SHEN Ming-hua.Protective effect of Armillariella mellea polysaccharide on liver injury mice induced by CCl4[J].Food Science and Technology,2011(10):170-172,177. |
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| Authors: | CUI Hai-dan WANG Xin-tong ZHAO Qin SHEN Ming-hua |
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| Affiliation: | CUI Hai-dan1,2,WANG Xin-tong1,ZHAO Qin2,SHEN Ming-hua1(1.College of Pharmaceutical Sciences,Yanbian University,Yanji 133000,2.School of Pharmaceutical Sciences,Jinlin University,Changchun 130021) |
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| Abstract: | Objective:To observe the protective effects of Armillariella mellea polysaccharide(AMP) on acute liver injury of mice induced by carbon tetrachloride(CCl4).Methods:Fifty mice were divided into five groups according to the weight;control group,carbon tetrachloride group,positive control group,low and high(200 mg/kg/d,100 mg/kg/d)dosage of AMP groups.All animals were sacrificed 24 hours after administered 0.1% carbon tetrachloride intraperitoneally.Then,the serum and liver tissue were examined by different ki... |
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| Keywords: | AMP liver injury antioxidant |
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