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Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity |
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| Authors: | Jie Liang Hong Qian |
| Affiliation: | [1]Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, U.S.A [2]Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China [3]Department of Applied Mathematics, University of Washington, Seattle, WA 98195, U.S.A [4]Kavli Institute for Theoretical Physics China, Chinese Academy of Sciences, Beijing 100190, China |
| Abstract: | Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathem... |
| Keywords: | biochemical networks cellular signaling epigenetics master equation nonlinear reactions stochastic modeling |
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