| 微波促L-苯丙氨酸消旋反应研究 |
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| 引用本文： | 刘毅,钱绍松,李加友,郭丽芸,贾晓娟,焦庆才.微波促L-苯丙氨酸消旋反应研究[J].化工进展,2005,24(8):893-896,900. |
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| 作者姓名： | 刘毅 钱绍松 李加友 郭丽芸 贾晓娟 焦庆才 |
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| 作者单位： | 南京大学生命科学学院医药生物技术国家重点实验室,南京,210093 |
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| 基金项目： | 国家技术创新基金（No.02CJ-13-01-16）资助. |
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| 摘 要： | 介绍了微波促L-苯丙氨酸消旋反应是一种新的可适合于工业化的生产方法，具有对环境友好的优点。使用微波作为热源不仅可加速反应和节约能源，也可提高反应的收率和产品的纯度。本方法确定了在微波辐射下，以1．0mol／L氢氧化钠水溶液替代低级脂肪酸作为反应溶剂，用物质的量比为0．10的水杨醛为催化剂，L-苯丙氨酸可以快速消旋；在此务件下，消旋反应随微波辐射功率的提高而加快，在66％输出功率下反应已接近最大反应速率。从实验中得出微波促L-苯丙氨酸消旋的反应是一级不可逆反应。考察了此消旋反应的影响因素，同时讨论了微波作用下L-苯丙氨酸的消旋反应机理。
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| 关 键 词： | L-苯丙氨酸 D-苯丙氨酸 消旋 微波辐射 过热效应 |
| 文章编号： | 1000-6613（2005）08-0893-04 |
| 收稿时间： | 2005-03-31 |
| 修稿时间： | 2005-03-312005-05-08 |
Microwave-assisted Rapid Racemization of L-Phenylalanine |
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| Liu Yi,Qian Shaosong,Li Jiayou,Guo Liyun,Jia Xiaojuan,Jiao Qingcai.Microwave-assisted Rapid Racemization of L-Phenylalanine[J].Chemical Industry and Engineering Progress,2005,24(8):893-896,900. |
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| Authors: | Liu Yi Qian Shaosong Li Jiayou Guo Liyun Jia Xiaojuan Jiao Qingcai |
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| Abstract: | A practical method for the racemization of LPhenylalanine by microwave irradiation was developed. Compared with the conventional methods of racemization, microwave dielectric heating promoted the racemization of LPhenylalanine, leading to a significant increase in reaction rates. There are two main advantages: (1) The whole process of racemization by this method can be completed within circa 1 h in the medium of 1.0 mol/L NaOH under reflux conditions for 1 h in the presence of 0.10 molar equivalent of salicylaldehyde by using 66% power of microwave (irradiation); (2) It is an economical, convenient and environmentally acceptable way to racemize (L)Phenylalanine. The factors influencing racemization were investigated. The racemization was found to follow firstorder reaction kinetics. The mechanism of racemization was discussed. |
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| Keywords: | L-phenylalanine D-phenylalanine racemization microwave irradiation superheating effects |
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