| 2-甲基-α-氧基苯乙酸甲酯的合成研究 |
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| 引用本文： | 陈灿,柳爱平,刘兴平,王胜德.2-甲基-α-氧基苯乙酸甲酯的合成研究[J].云南化工,2004,31(6):9-11. |
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| 作者姓名： | 陈灿 柳爱平 刘兴平 王胜德 |
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| 作者单位： | 1. 湖南化工研究院,湖南,长沙,410007
2. 湖南师范大学,湖南,长沙,410081 |
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| 摘 要： | 2-甲基苯甲酰腈水解制2-甲基-α-氧基苯乙酸甲酯中,物质量比n(2-甲基苯甲酰腈):n(NaCl):n(浓H_2SO_4):n(H_2O)=10∶1∶10∶10,反应温度维持在45℃,反应1.0h,再加入甲醇回流1.5h,可得纯度为90.69%的产物2-甲基-α-氧基苯乙酸甲酯,收率为77.99%.
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| 关 键 词： | 2-甲基苯甲酰腈 2-甲基-α-氧基苯乙酸甲酯 浓硫酸 水解 |
| 文章编号： | 1004-275X(2004)06-0009-03 |
Synthesis of Methyl 2-methyl-α-oxophenylacetate |
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| CHEN Can LIU Ai-ping LIU Xing-ping WANG Sheng-de.Synthesis of Methyl 2-methyl-α-oxophenylacetate[J].Yunnan Chemical Technology,2004,31(6):9-11. |
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| Authors: | CHEN Can LIU Ai-ping LIU Xing-ping WANG Sheng-de |
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| Affiliation: | CHEN Can~1 LIU Ai-ping~1 LIU Xing-ping~1 WANG Sheng-de~2 |
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| Abstract: | Methyl 2-methyl-(-oxophenylacetate was synthesized by the hydrolysis of 2-methyl-α-oxobenzoyl cyanidewith concentrated sulfuric acid.Effect of concentrated sulfuric acid,reaction temperature,time and solvent on yields wasstudied.The ratio of 2-methyl-α-oxobenzoyl cyanide:sodium chloride:water:concentrated sulphuric acid was chosen as 10:1:10:10 and the mixture was kept in 45℃ for one hour to give the yield of 78%,with purity of 90.69%. |
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| Keywords: | 2-methyl-α-oxobenzoyl cyanide methyl 2-methyl-α-oxophenylacetate concentrated sulfuric acid hydrolysis |
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