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| 4种有机硒衍生物的合成与活性研究 | |
| 引用本文： | 张华,张锦胜,王晗.4种有机硒衍生物的合成与活性研究[J].化学试剂,2009,31(7). |
| 作者姓名： | 张华 张锦胜 王晗 |
| 作者单位： | 1. 上海工程技术大学,化学化工学院,上海,201620;上海交通大学,农业与生物学院,上海,200240 2. 南昌大学,中德食品工程中心,江西,南昌33,]029 3. 上海工程技术大学,化学化工学院,上海,201620 |
| 基金项目： | 上海高校优秀青年教师后备人选培养计划项目 |
| 摘 要： | 以依布硒啉为先导化合物,以邻氯硒基苯甲酰氯为中间体,分别合成4种未见报道的新型有机硒化合物,并用LR、1HNMR、元素分析进行表征.经抗肿瘤生物活性体外筛选实验表明,2007-1和2007-4对肿瘤细胞的生长有明显的抑制作用. |
| 关 键 词： | 有机硒化合物 合成 肿瘤细胞抑制作用 |
Synthesis and study on activity of four benzisoselenazolone derivatives |
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| ZHANG Hua,ZHANG Jin-sheng,WANG Han.Synthesis and study on activity of four benzisoselenazolone derivatives[J].Chemical Reagents,2009,31(7). | |
| Authors: | ZHANG Hua ZHANG Jin-sheng WANG Han |
| Affiliation: | 1.Shanghai University of Engineering Science;Shanghai 201620;China;2.College of Agriculture and Biology;Shanghai Jiaotong University;Shanghai 200240;3.Nanchang University;Nanchang 330029;China |
| Abstract: | Four novel organoselenium compounds have been synthesized and their structures have been characterized by elemental analysis,IR and 1HNMR.Results on testing of biological activity of these compounds indicated their outstanding growth inhibiting function to human liver cancer cells. |
| Keywords: | organoselenium compounds synthesis antitumor activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |