Liver desaturase activities and FA composition in monkeys. Effect of a low-protein diet |
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Authors: | Email author" target="_blank">María?C?MarínEmail author Héctor?M?Pucciarelli María?J?T?de?Alaniz |
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Affiliation: | (1) Facultad de Ciencias Médicas, Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), 60 y 120, (1900) La Plata, Buenos Aires, Argentina;(2) Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, (1900) La Plata, Buenos Aires, Argentina |
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Abstract: | The aim of the present study was to measure Δ9-, Δ6-, and Δ5-desaturase activities in liver microsomes, as well as phospholipid
FA composition of liver and erythrocytes in monkeys fed a control or low-protein diet during the postweaning period. Ten Saimiri sciureus boliviensis (Cebidae) of both sexes were employed; at 12 mon of age they were separated into two groups fed ad libitum on a control or a low-protein diet for 24 mon. Saimiri sciureus had active Δ9, Δ6, and Δ5 liver desaturase enzymes, and these activities were influenced by the diet. A low-protein diet
produced a significant reduction in Δ5-desaturation capacity, an increase in Δ9-desaturase activity, and no change in Δ6-desaturase
activity (P<0.05). These changes, evoked by protein deprivation, were reflected in the liver phospholipid FA composition. Increases in
the proportion of saturated FA and in monounsaturated oleic acid (18∶1n−9) and a decrease in the proportion of PUFA of the
n−6 and n−3 series were produced in the animals fed a low-protein diet (P<0.0001). Differences between the two dietary groups were less pronounced in the FA composition of erythrocyte phospholipids.
The authors are members of the Carrera del Investigador del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET),
Argentina. |
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