Optimal feeding profile in fed-batch bioreactors using a genetic algorithm

An optimal feeding profile for a fed-batch process was designed based on an evolutionary algorithm. Usually the presence of multiple objectives in a problem leads to a set of optimal solutions, commonly known as Pareto-optimal solutions. Evolutionary algorithms are well suited for deriving multi-objective optimisation since they evolve a set of non-dominated solutions distributed along the Pareto front. Several evolutionary multi-objective optimisation algorithms have been developed, among which the Non-dominated Sorting Genetic Algorithm NSGA-II is recognised to be very effective in overcoming a variety of problems. To demonstrate the applicability of this technique, an optimal control problem from the literature was solved using several methods considering the single-objective dynamic optimisation problem.