茶多酚对家犬的长期毒性作用

目的 观察用药 90 d 及停药 2 kw 后,茶多酚(TP)对家犬的长期毒性反应 。方法 家犬以 650、65、6.5 mg·kg^-1·d^-13个剂量分别连续饲服 TP90 d 及停药 2 kw 后,观察动物的一般情况、检查动物的心电图、血尿常规 、血脂、血糖 、凝血时间 、肝肾功能等生化指标。结果 用药组体重增加情况与对照组无显著性差异(P>0.05);用药前 、服药中、停药后家犬的活动情况、毛发 、粪便、心电图 、血尿常规 、各项生化指标均未见异常,用药前后比较无显著性差异(P>0.05);大、中 、小剂量组血清胆固醇水平进行性降低 。结论 TP按 650 mg·kg^-1·d ^-1饲服 90 d 对家犬未见明显毒性作用。

Chronic toxicity of tea polyphenols in dogs

Aim The chronic toxicity of tea polyphenols(TP)in dogs was observed.Methods 18 dogs were randomly divided into high,middle and low dose TP groups and one control group.When TP was given(po)by 650mg·kg^-1·d^-1,65mg·kg^-1·d^-1,6.5mg·kg^-1·d^-1re-spectively for 90 d and after TP was stopped for two weeks,the general conditions,ECG,blood routine,urine routine,serum lipids,blood sugar,coagulation time,and hepatic and kidney function were detected respectively.Results These mdices were not different from each other among the 4 groups before,during and after administration of TP.The level of serum total cholesterol was progressively decreased in TP groups.Conclusion TP has no toxic effect on dogs and can decrease the level of serum total cholesterol in normal dogs.