| 三七总皂甙对大鼠局灶性脑缺血的保护作用 |
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| 引用本文： | 史以菊,吴俊芳,夏作理,邢国庆.三七总皂甙对大鼠局灶性脑缺血的保护作用[J].金属学报,1999,4(4):272-275. |
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| 作者姓名： | 史以菊 吴俊芳 夏作理 邢国庆 |
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| 作者单位： | 山东泰山医学院药理救研室,泰安 271000;1.中国医学科学院药理研究所 |
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| 摘 要： | 目的 研究三七总皂甙(PNS)对大鼠局灶性脑缺血的保护作用。方法 阻断大鼠大 脑中脉造成可逆性脑缺血模型,观察PNS对缺血脑组织的保护作用。结果 PNS 20、40 mg·kg-1·d-1x10d能显著改善大鼠MCAO后的神经功能障碍,缩小脑梗塞面积,减轻脑水肿,并能降低缺血脑组织的总钙含量,明显提高SOD活力,降低MDA含量。结论 PNS对局灶性缺血脑组织具有保护作用,其机理推测与降低脑组织钙含量及抗氧自由基损伤有关。
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| 关 键 词： | 三七总皂甙 局灶性脑缺血 氧自由基 钙 大鼠 |
| 收稿时间： | 1999-09-30 |
| 修稿时间： | 1999-11-02 |
Protective effects of punax notojinseg on local cerebral ischemia in rats |
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| SHI Yi-Ju,WU Jun-Fang,XIA Zuo-Li,XING Guo Qing.Protective effects of punax notojinseg on local cerebral ischemia in rats[J].Acta Metallurgica Sinica,1999,4(4):272-275. |
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| Authors: | SHI Yi-Ju WU Jun-Fang XIA Zuo-Li XING Guo Qing |
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| Affiliation: | Department of phar macology, Taian Medical College, Taian 271000;1.Institute of Materia Medica, Chinese Academy of Medical Science |
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| Abstract: | Aim To study the protective effects of punax notojinseg (PNS) on local cerebral ischemia in rats. Methods Local cerebral ischemia in rats was induced by occlusion of the middle cerebral artery (MCAO) without craniectomy.Results PNS in the doses of 200 and 400 mg·k-1·d-1x 10 d significantly decreased the infarct size and brain edema and ameliorated neurologic deficits in rats subjected to MCAO for 2 or 24 hours. The same dosage of PNS could markedly increase the activity of superoxide dismutase (SOD) and decrease the concentration of malondialdehyde (MDA) and Ca2+ in the brain.Conclusions Declining free radicals and decreasing Ca2+ content in brain might be one of the important factors involved in the anti-cerebral ischemia effect of PNS. |
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| Keywords: | punax notojinseg cerebral ischemia free radicals calcium cerebral infarction rat |
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