| 全反式维甲酸和阿糖胞苷对HL-60细胞端粒酶活性的影响 |
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| 引用本文： | 吴向华,叶开和,胡爱群. 全反式维甲酸和阿糖胞苷对HL-60细胞端粒酶活性的影响[J]. 金属学报, 2000, 5(1): 47-48 |
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| 作者姓名： | 吴向华 叶开和 胡爱群 |
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| 作者单位： | 暨南大学医学院,广州 510630;1.皖南医学院,芜湖 241001 |
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| 摘 要： | 目的 探讨全反式维甲酸(all trans-retinoic acid,ATRA) 和阿糖胞苷(Ara-c) 诱导人早幼粒细胞白血病细胞凋亡和分化的机制。方法 采用PCR-ELISA 方法观察A TRA 和Ara-c 对HL-60细胞端粒酶活性的影响。结果 ATRA 和Ara-c 在诱导HL-60 细胞凋亡和分化过程中均可使端粒酶活性减低。结论 ATRA 和Ara-c抑制HK-60 细胞端粒酶的活性,可能是其诱导白血病细胞凋亡和分化的重要机制之一。
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| 关 键 词： | HL-60 细胞 端粒酶活性 全反式维甲酸 阿糖胞苷 |
| 收稿时间： | 2000-01-19 |
Ef fect of the all trans retinoic acid and Ara-con the telomerase activity of HL-60 cells |
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| WU Xiang-Hua,YE Kai-He,HU Ai-Qun. Ef fect of the all trans retinoic acid and Ara-con the telomerase activity of HL-60 cells[J]. Acta Metallurgica Sinica, 2000, 5(1): 47-48 |
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| Authors: | WU Xiang-Hua YE Kai-He HU Ai-Qun |
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| Affiliation: | Medical college of Jinan University,Gangzhou 510630;1.Wannan Medical College,Wuhu 241001 |
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| Abstract: | Aim To investigate the possible mechanism of human promyelocytic leukemia cells differentiation and apoptosis induced by all trans-retinoic acid (ATRA)and A ra-c.Methods The effects of AT RA and Ara-c on the tolomerase activity of HL-60 cells were detected by PCR-E LISA.Results The tolome rase activity of HL-60 cells declined during the course of differentiation and apoptosis induced by AT RA and Ara-c.Conclusion These finding ssuggest that AT RA and Ara-c can inhibit tolomerase activity of HL-60 cells.It may be one of the important mechanisms of human promyelocytic leukemia cells differentiation and apo ptosis induced by ATRA and Ara-c. |
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| Keywords: | HL-60 cell telomerase activity alltrans-re tinonic acid cytosirearabinoside |
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