保心包贴膜对稳定型心绞痛患者血浆内皮素和一氧化氮水平的影响

目的 研究保心包贴膜对稳定型心绞痛(SAP)患者血浆内皮素(ET)和一氧化氮(NO)水平的影响。方法 76例SAP患者随机单盲分为保心包组和硝酸异山梨酯组,分别给予保心包贴膜外敷心前区,每片4d(首次2片),共6片20d;硝酸异山梨酯10mg,每日3次,po。观察治疗前后血浆ET和NO水平。结果 SAP患者治疗前血浆ET和NO水平分别显著高于和低于正常对照组(均P<0.01);治疗后保心包组和硝酸异山梨酯组ET和NO代谢失衡均显著改善,但以保心包组改善更为显著(P<0.05)。结论 保心包贴膜显著改善SAP患者ET和NO的代谢失衡,可能是其有效缓解心绞痛的机理之一。

Effect of baoxinbaofilm on plasma endothel in and nitricoxide levels in patients with stable angina pectoris

Aim To study the Effect of Baoxinbaofilm on endothelin(ET)and nitricoxide(NO)secretion in patients with stable angina pectoris(SAP).Methods 76 patients with SAP wererandomly dividedinto two groups, with 40 cases in the baoxinbao group plastered with baoxinbaofilm and 36 cases in the isosorbide dinitrate groupreceiving isosorbide dinitrate. The levels of plasma E T and NO beforeand after treatment wereobserved.Results The concentrations of plasma E T wereincreased and plasma NO reduced significant ly in the SAP patients respectively, as compared with those in the control group(all P<0.01).After treatment the metabolic imbalance of ET and NO was improved markedly in both Baoxinbao andisosorbide groups(P<0.05, P<0.01), but the imbalance of ET and NO in the Baoxinbao group was improved moreobviously than thatin the isosorbide group(P<0.05).Conclusion Baoxinbaofilm can obviously improve the metabolic imbalance of ET and NO secretion,which results in the effective alleviation of angina pectoris in patients with SAP.