脑络通胶囊对鹌鹑实验性动脉粥样硬化的预防作用

目的 探讨脑络通胶囊抗动脉粥样硬化(AS)作用。方法 制备鹌鹑AS 模型, 120 只♂鹌鹑随机分为6 组:正常对照组、高脂对照组、月见草油丸组、脑络通大、中、小剂量组。结果 脑络通可使鹌鹑升高的血脂(TC、TG、LDL-C 和VLDL-C)水平进行性降低, (P<0.05、P<0.01), 使HDL-C 水平或HDL-C/TC 值升高(P<0.05、P<0.01), 并降低主动脉和心肌中TC、TG 含量(P<0.05), 对主动脉和冠状动脉内膜粥样斑块形成有明显的抑制作用(P<0.05、P<0.01)。结论 脑络通有调脂作用和抗AS 作用。

Preventive effect of Naoluotang,a compound of Chinese medicine on experimental atherosclerosis in quails

Aim The effects of Naoluotong, a cempeund of Chinese medicine on atherosclerosis were studied.Methods One hundred and twenty male quails were divided at random into 6 groups.The quaits in 5 groups, including the control group,Naoluotong (3, 6, 12 g·kg^-1·d^-1)groups, and Yuejiancao oil (6 g·kg^-1·d^-1)group, received hyper-f at forage, and in the six th group were fed on stock diet.Half of the quails in each group were kill 4 wk after.The levels of TC, TG, LDL-C,V LDL-C and HDL-C in serum were measured in Biochemilal method.The remainder quails were fed on above forege continuously for another 4 wk and then were killed.The levels of TC, TG, LDL-C,V LDL-C and HDL-C in serum and the contents of TC and TG in myocardium and aorta were tested, and the change of endo-aorta was determined.Results The levels of TC, TG, LDL-C and V LDL-C were decreased, the level of HDL-C and the v atio of HLD-C/TC were increased by Naoluotong (6, 12 g·kg^-1·d^-1)in the quails fed on hyper fat forage for 4wk (P<0.05, P<0.01).In the remainder quails which were raised for 8wk, the above items were similar to the quails fed for 4wk, the effelts of Naoluotong was dose-d ependent in adjusting blood lipid, and the contents of TC and TG in aorta and myo cardium were decreased (P<0.05)and the lesion of endo-aorta was also improved by Naoluotong (6, 12 g·kg^-1·d^-1). Conclusion Naoluotong has the action to adjust blood lipid-adjusting and to antag ouise atherosclerosis.