阿奇霉素与头孢唑啉治疗呼吸道感染的临床对照研究

目的 评价国产阿奇霉素针剂治疗呼吸道感染的临床疗效及其安全性。方法 采用开放对照方法,将50例呼吸道细菌感染患者随机分为试验组和对照组。试验组给阿奇霉素针剂250mg·d^-1,qd,iv,5d,首剂加倍;对照组给头孢唑啉2g/次,bid,iv,5~10d。结果 两组在综合临床疗效方面无显著差异;试验组痊愈率46.67%,有效率为90%、不良反应率3.3%;对照组痊愈率60%、有效率95%、不良反应率0%。结论 国产阿奇霉素针剂用于呼吸道感染的治疗是有效、安全的。

Clinical study of azithromycin and cefazol in in treatment of respiratory tractinfections

Aim To evaluate the effect and safety of azithromycin injection producedin China and cefazolin in the treatment of respiratory tractinfections.Methods 50 patients with respiratory tractinfections weredivided randomly into two groups.Patients in the test grouprecieved azithromycin in the dosage of 250 mg·d^-1, qd for 5 div with double dosages at the fi rst timeand patients in the control grouprecieved cefazolin in the do sage of 2.0 g, bid, iv for 5 ~ 10 d.Results No statistical significant differences of overall clinical Effect wereobserved between two groups.The fully recovery, Effective and sidereaction rates for the test group were46.67 %, 90% and 3.3 %, respectively, and for control group the data were60 %, 95 %, and 0 %, respectively.Conclusion Azithromycin injection producedin China is effective and safe in the treatment of respiratory infections.