Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment |
| |
| Authors: | Hochung Jang Eun Hye Kim Sung-Gil Chi Sun Hwa Kim Yoosoo Yang |
| |
| Affiliation: | 1.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea; (H.J.); (E.H.K.);2.Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea;3.Department of Life Sciences, Korea University, Seoul 02841, Korea; |
| |
| Abstract: | A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments. |
| |
| Keywords: | nanoparticles innate immune cells tumor microenvironment cancer therapy |
|
|
