| 己二酸二酰肼交联透明质酸薄膜的制备及性能研究 |
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| 引用本文： | 徐新,陆明秋,叶玟希,董华平,施丹萍. 己二酸二酰肼交联透明质酸薄膜的制备及性能研究[J]. 广东化工, 2012, 39(2): 47-48 |
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| 作者姓名： | 徐新 陆明秋 叶玟希 董华平 施丹萍 |
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| 作者单位： | 绍兴文理学院化学化工学院,浙江绍兴,312000 |
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| 基金项目： | 浙江省大学生科技成果推广项目资助（029001.35） |
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| 摘 要： | 利用己二酸二酰肼(ADH)作为交联剂,对HA分子进行化学修饰,制备出HA-ADH凝胶薄膜。利用差示扫描量热仪(DSC)和红外光谱(FTIR)对交联产物HA-ADH的结构进行表征,证实了交联反应的发生。当HA与ADH质量比为1∶8时,薄膜的性能最好。通过对HA-ADH薄膜的皮肤刺激性试验进行考察,发现经交联后的HA-ADH薄膜具有良好的生物相容性。
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| 关 键 词： | 己二酸二酰肼 透明质酸 交联 生物相容性 |
Synthesis and Characterization of Cross-linking Hyaluronic Acid Film by ADH |
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| Xu Xin,Lu Mingqiu,Ye Minxi,Dong Huaping,Shi Danping. Synthesis and Characterization of Cross-linking Hyaluronic Acid Film by ADH[J]. Guangdong Chemical Industry, 2012, 39(2): 47-48 |
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| Authors: | Xu Xin Lu Mingqiu Ye Minxi Dong Huaping Shi Danping |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Shaoxing 312000,China) |
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| Abstract: | The gel film of HA-ADH was synthesized by chemical modification of hyaluronic acid（HA） with adipic dihydrazide（ADH）.The structure of HA-ADH was determined by differential scanning calorimeter（DSC） and Fourier transform infrared spectroscopy（FTIR）,and the cross-linking reaction between HA and ADH was confirmed.The optimum proportion of HA and ADH for the performance of HA-ADH was set as 1∶8.HA-ADH film showed good biocompatibility by the study on the test of skin irritation of HA-ADH. |
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| Keywords: | Adipic dihydrazide hyaluronic acid cross-linking biocompatibility |
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