| 阿司匹林合成实验改进 |
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| 引用本文： | 谭伟,杜志云,卢宇靖,张磊. 阿司匹林合成实验改进[J]. 广东化工, 2012, 39(1): 8-8,158 |
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| 作者姓名： | 谭伟 杜志云 卢宇靖 张磊 |
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| 作者单位： | 广东工业大学轻工化工学院,广东广州,510006 |
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| 基金项目： | 广东工业大学质量工程项目（20102029,402102229） |
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| 摘 要： | 以水杨酸和乙酰氯为原料,浓硫酸为催化剂合成阿司匹林。结果表明,当水杨酸用量为2.0 g,乙酰氯用量为5 mL,浓硫酸用量为1 mL时,85℃反应15 min,阿司匹林收率可达73.8%,比同等条件下乙酸酐的收率提高了20%左右。
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| 关 键 词： | 阿司匹林 水杨酸 乙酰氯 乙酸酐 |
Experimental Improvement of Aspirin Synthesis |
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| Tan Wei,Du Zhiyun,Lu Yujing,Zhang Lei. Experimental Improvement of Aspirin Synthesis[J]. Guangdong Chemical Industry, 2012, 39(1): 8-8,158 |
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| Authors: | Tan Wei Du Zhiyun Lu Yujing Zhang Lei |
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| Affiliation: | (Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China) |
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| Abstract: | Aspirin was synthesized using raw materials of salicylic acid and acetyl chloride, which was catalyzed by concentrated sulphuric acid. Results were showed that yield of aspirin was reached 73.8 % under as follow conditions： salicylic 2.0 g, acetyl chloride 5 mL, concentrated sulphuric acid 1 mL, temperature 85℃ , reaction 15 rain. Compared with acetic anhydride, yield of aspirin was enhanced about 20 % at status conditions. |
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| Keywords: | Aspirin salicylic acid acetyl chloride acetic anhydride |
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