黄烷醇类化合物的药理活性研究进展

黄烷醇类化合物是一类常见的天然植物多酚类化合物包括儿茶素类、花色素类及黄酮类等化合物,大部分存在于多种木本植物组织中,如山楂、葡萄、可可粉、苹果及草莓等,与日常的饮食有着非常密切的联系。近年以来,国内外许多学者对黄烷醇类化合物进行了研究,多项研究结果表明黄烷醇类化合物具有多种保健功能及生物活性作用,如清除自由基、抗氧化、抗肿瘤、抗炎、抗真菌、降血脂、保护肝脏、保护心血管等,也已被很多的药物科学研究所证实,并成为当今开发研究的热点。本文主要对天然黄烷醇类化合物的来源及多种药理活性等作用进行了综述,并对我国黄烷醇类化合物开发的应用前景提出了一些建议,对黄烷醇类化合物取代合成药物应用于保健食品等行业提供了较好的参考。

Advances in research on pharmacological activities of flavanol compounds

The flavanol compounds are a class of common and natural plant poly-phenols, including catechins, anthocyanidins, flavonoids and other compounds, which exist in various woody such as hawthorn, grapes, cocoa powder, apple and strawberry, and have close relation with the daily diet. In recent years, there had been many homeland and abroad reported studies about flavanol compounds, which had indicated that they had a variety of healthy and biological activities, such as alleviation of free radicals damage, antioxidant, antitumor, anti-inflammatory effect, anti-fungal, hypolipaemic, liver protection, cardiovascular protection and so on, confirmed by many drug results and experiments, and become a central issue of research and development. The article mainly reviewed the sources and pharmacological activity of these natural compounds, and suggestions were also provided for the future application of flavanol compounds in China, which provided a good reference replace synthetic drugs used in health food and other industries in future.