Natural origin hydroxyapatite scaffold as potential bone tissue engineering substitute |
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| Affiliation: | 1. Instituto de Física, Benemérita Universidad Autónoma de Puebla, Apdo. Postal J-45, Puebla, Puebla 72570, Mexico;2. Department of Biotechnology, National Institute of Technology Durgapur, M.G. Avenue, Durgapur 713209, Burdwan, West Bengal, India;1. Department of Orthopaedic Surgery, Pusan National University Hospital, Busan 602-739, Republic of Korea;2. Department of Medicine, Graduate School, Pusan National University, Busan 602-739, Republic of Korea;3. Department of Marine Bio Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea;4. Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500-007, India;5. Department of Pathology, Medical College, Kosin University, Busan 602-739, Republic of Korea;1. Center for Advanced Manufacturing & Material Processing, Department of Mechanical Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia;2. Division of Neurosurgery, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia;3. Centre for Ionics University of Malaya, Department of Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;4. Ceramics Technology Group, SIRIM Berhad, Shah Alam 40911, Malaysia;1. Department of Mechanical Engineering, Rajiv Gandhi University of Knowledge Technologies (AP-IIIT), Nuzvid 521202, India;2. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036, India;1. Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Republic of Korea;2. Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Busan 48513, Republic of Korea;3. Department of Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan 48513, Republic of Korea;1. Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513 Republic of Korea;2. Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan, Republic of Korea |
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| Abstract: | Fish scales derived natural hydroxyapatite (FS-HAp) scaffolds were prepared through solvent casting technique, which could mimic the structure of cortical and cancellous bone tissues of body system. The hydroxyapatite (HAp) biomaterial was synthesized by thermal decomposition of chemically treated fish scales. Fabricated scaffolds were characterized through morphological analysis, volumetric shrinkage, mechanical tests, and in vitro, in vivo biological studies. The projected scaffolds successfully mimic the cancellous/cortical bone system in terms of structure, porosity, mechanical strength, and exhibit excellent bioactive behavior. The FS-HAp scaffolds manifest good mechanical behaviors with Vickers Hardness (HV) of ~0.78 GPa, 0.52 GPa compressive stress, 190 MPa tensile stress and ~35% porosity on sintering at 1200 °C. In vitro and in vivo studies suggest these nontoxic HAp scaffolds graft with osteoconductive support, facilitating new cell growth on the developed scaffold surface. The graded grafts have a great potential for application as traumatized tissue augmentation substitute, and ideal for load-bearing bone applications. |
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| Keywords: | Fish scale Hydroxyapatite Scaffold Bone tissue |
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