Glycosidase activities in bovine milk over lactation |
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| Affiliation: | 1. Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland;2. Glycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, Ireland;1. ITHES (UBA-CONICET), Laboratorio de Procesos Catalíticos, Departamento de Ing. Química, Facultad de Ingeniería, Universidad de Buenos Aires, Pabellón de Industrias, Ciudad Universitaria, 1428 C.A.B.A., Argentina;2. INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428 C.A.B.A., Argentina;1. Research Institute for Pesticides and Water, Universitat Jaume I, E-12071 Castellón, Spain;2. Departament de Química Inorgànica i Orgànica, Universitat Jaume I, E-12071 Castellón, Spain;1. Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;2. Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;3. Department of Pathology, Kashgar Prefecture Second People''s Hospital, Urumqi, China;4. Department of Oncology, Fuzhou Pulmonary Hospital, Shanghai, China;5. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;1. Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan;2. Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;3. Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan;1. Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Spain;2. Research Institute for Pesticides and Water, University Jaume I, 12071, Castellón, Spain;3. Integrative Pharmacology and Systems Neuroscience Group, IMIM, Hospital del Mar Medical Research Institute, Doctor Aiguader 88, 08003 Barcelona, Spain |
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| Abstract: | The presence and activity of glycosidases in Irish bovine milk over three months of lactation was investigated. A low level of variation between animals was observed and the highest level of glycosidase activity was present in colostrum, decreasing through transitional milk production to minimal but constant levels in mature milk. N-acetyl-β-d-glucosaminidase, α-l-fucosidase, α-galactosidase and N-acetyl-neuraminidase appear to be the most biologically relevant glycosidases in bovine milk. The elevated levels of enzymatic activity in colostrum suggests the milk glycosidases may play a role in the digestion of bovine milk glycans in the infant mammal, possibly acting as substitutes for bacterial glycosidases prior to colonisation by the gut microflora, which are involved in in vivo oligosaccharide metabolism in the lower gastrointestinal tract. |
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