| D／L邻氟扁桃酸的合成研究 |
| |
| 引用本文： | 刘飞孟,林原斌,陈红飙.D／L邻氟扁桃酸的合成研究[J].有机氟工业,2004(1):7-9. |
| |
| 作者姓名： | 刘飞孟 林原斌 陈红飙 |
| |
| 作者单位： | 湘潭大学化学学院
(刘飞孟，林原斌)，湘潭大学化学学院(陈红飙) |
| |
| 摘 要： | 以邻甲苯胺为原料，经过氟化、氧化成邻氟苯甲酸，与氯化亚砜反应得到邻氟苯甲酰氯，再与CH3CH2OMgCH(COOCH2CH3)2反应，水解脱羧得到邻氟苯乙酮，经过氯化、水解、重排得到高纯度的邻氟扁桃酸，总收率达38．8％，高效液相色谱分析(流动相V甲醇：V水=7：3)含量为98．2％。
|
| 关 键 词： | 邻氟扁桃酸 邻甲苯胺 邻氟苯乙酮 氟化反应 高效液相色谱分析 |
Studies on Synthesis of D/L o-Fluoromandelic acid |
| |
| Liu Feimeng,Lin Yuanbin,Chen Hongbiao.Studies on Synthesis of D/L o-Fluoromandelic acid[J].Organo-Fluorine Industry,2004(1):7-9. |
| |
| Authors: | Liu Feimeng Lin Yuanbin Chen Hongbiao |
| |
| Abstract: | A novel method for preparing o-Fluoromandelic acid consists in the chlorination and hydrolysis and rearrangement o-Fluoroacetophenone, which obtained hydrolysis and decarboxycation the production of acylation of the magnesiumethoxy derivative of diethyl malonate with o-Fluorobenzoic chloride, o-Fluorobenzoic acid was syn-thesized by Schiemann-reaction of o-methylaniline to give o-Fluorotoluene which was oxidized by HN03 in an autoclave. The whole yield reached to 38.9% with 98.2% purity. |
| |
| Keywords: | o-Fluoromandelic acid o-Fluoroacetophenone o-tolidine Fluorination |
| 本文献已被 CNKI 维普 等数据库收录！ |
