| 新型骨-软骨一体化修复支架材料的制备 |
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| 引用本文： | 任力,季培红,黄志芳,王迎军.新型骨-软骨一体化修复支架材料的制备[J].复合材料学报,2011,28(1):99-103. |
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| 作者姓名： | 任力 季培红 黄志芳 王迎军 |
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| 作者单位： | 1.华南理工大学 特种功能材料教育部重点实验室, 广州 510640; |
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| 基金项目： | 国家自然科学基金(50732003,50803018,50830101); 国家科技支撑计划(2006BAI16B06,2006BA116B04); 国家973项目(2005CB623902); 广东省自然科学基金(04205786) |
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| 摘 要： | 利用可降解聚合物微球的相互粘结制备了一种新型的组织工程支架材料, 可用于软骨和软骨下骨损伤的修复。采用光学显微镜、 扫描电镜对支架的表面形貌、 内部结构进行了表征, 同时研究了支架材料的力学性能, 此外还研究了微球的粒径对支架材料孔隙率的影响。结果显示, 该材料在结构上分为乳酸-羟基乙酸共聚物(PLGA)层和PLGA/生物活性玻璃(BG)层; 材料的孔隙三维连通、 分布均匀; 采用粒径为150~200μm微球所制备的支架孔隙率为(53.37±4.39)%, 在10%的应变下材料压缩强度便已达到了0.9MPa, 显示了较强的力学性能; 随着微球粒径的变小, 材料孔隙率逐渐增大。这种微球支架在骨-软骨组织缺损修复方面有着很大的研究价值和应用价值。
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| 关 键 词： | 软骨 微球 支架 PLGA 生物活性玻璃 |
| 收稿时间： | 2010-01-26 |
| 修稿时间： | 2010-04-29 |
Novel biodegradable scaffolds for bone and cartilage repair |
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| REN Li,JI Peihong,HUANG Zhifang,WANG Yingjun.Novel biodegradable scaffolds for bone and cartilage repair[J].Acta Materiae Compositae Sinica,2011,28(1):99-103. |
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| Authors: | REN Li JI Peihong HUANG Zhifang WANG Yingjun |
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| Affiliation: | 1.Key Laboratory of Specially Functional Materials, South China University of Technology, Ministry of Education, Guangzhou 510640, China;2.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China |
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| Abstract: | A novel biodegradable scaffold was prepared by utilizing polymer microspheres as the building blocks for scaffold formation.This saffold can be used for cartilage and bone repair.Optical microscope,SEM method were used to investigate the inside and the surface characteristics of the scaffold.The mechanical performance and the porosity of the scaffold were also tested.Results show that this scaffold consists of two distinct yet continuous phases,one is composed by poly(L,D-lactic-co-glycolic acid)(PLGA) micr... |
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| Keywords: | osteochondral microsphere scaffold PLGA bioglass |
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