Abstract: | The adenosine triphosphate (ATP depletion ratio, which is the ratio ATP] in skeletal muscle equilibrated with carbogen and 4% halothane for 30 minutes divided by ATP] in skeletal muscle equilibrated with carbogen alone for 30 minutes is less than normal in most but not in all rigid MHS patients. The ratio is normal in non-rigid MHS patients. This diagnostic tool is, therefore, useful in the diagnosis of rigid MH. It is not, however, such a sensitive diagnostic parameter as the caffeine contracture test. |