Dietary Micronutrient Management to Treat Mitochondrial Dysfunction in Diet-Induced Obese Mice |
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| Authors: | Fabiano Cimmino Angela Catapano Giovanna Trinchese Gina Cavaliere Rosanna Culurciello Chiara Fogliano Eduardo Penna Valeria Lucci Marianna Crispino Bice Avallone Elio Pizzo Maria Pina Mollica |
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| Affiliation: | 1.Department of Biology, University of Naples Federico II, 80126 Naples, Italy; (F.C.); (A.C.); (G.T.); (G.C.); (R.C.); (C.F.); (E.P.); (V.L.); (M.C.); (B.A.); (E.P.);2.Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy;3.IEOS, Institute of Experimental Endocrinology and Oncology “G. Salvatore”—National Research Council, 80131 Naples, Italy |
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| Abstract: | Obesity and associated metabolic disturbances, which have been increasing worldwide in recent years, are the consequences of unhealthy diets and physical inactivity and are the main factors underlying non-communicable diseases (NCD). These diseases are now responsible for about three out of five deaths worldwide, and it has been shown that they depend on mitochondrial dysfunction, systemic inflammation and oxidative stress. It was also demonstrated that several nutritional components modulating these processes are able to influence metabolic homeostasis and, consequently, to prevent or delay the onset of NCD. An interesting combination of nutraceutical substances, named DMG-gold, has been shown to promote metabolic and physical wellness. The aim of this research was to investigate the metabolic, inflammatory and oxidative pathways modulated by DMG-gold in an animal model with diet-induced obesity. Our data indicate that DMG-gold decreases the metabolic efficiency and inflammatory state and acts as an antioxidant and detoxifying agent, modulating mitochondrial functions. Therefore, DMG-gold is a promising candidate in the prevention/treatment of NCD. |
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| Keywords: | mitochondria non-communicable diseases oxidative stress inflammation obesity micronutrients dimethylglycine vitamin B |
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