Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice |
| |
Authors: | RJ Gulizia RG Collman JA Levy D Trono DE Mosier |
| |
Affiliation: | Department of Immunology-IMM7, The Scripps Research Institute, La Jolla, California 92037, USA. |
| |
Abstract: | The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|