| BPHA二价金属离子配合物的结构与99Tcm-BPHA生物分布的关系 |
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| 作者姓名： | 刘国正 刘 飞 杨 霆王翌善 缪增星方吉东 |
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| 作者单位： | ：中国原子能科学研究院同位素研究所,北京,102413 |
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| 摘 要： | The protonation constants ofBPHA and its complexes of divalent metal ions Co2+,Ni2+,Cu2+,and Zn2+ are determined by potentiometric titration and non-linear regression.The 1H NMR spectra of Zn2+-BPHA at pD=2～12 is obtained onVarian-200. It proves that at pH≈6 the complex Zn(Ⅱ) H2BPHA2-loses a proton and a formerly free iminodiacetic acid moiety becomes coordinated; at pH≈9the last proton is dissociated and an iminodiacetic acid moiety is released again. The 99Tcmlabelled product obtained at pH=7 is completely excreted through kidneys, different fromthe product forming at pH=4, which is taken up by liver considerably.
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| 关 键 词： | 胺羧配位剂 配合物 加质子常数 |
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