| 1,2,3-三-O-乙酰基-5-脱氧-D-呋喃核糖合成工艺研究 |
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| 引用本文： | 张文楠,黄险峰,宋国强.1,2,3-三-O-乙酰基-5-脱氧-D-呋喃核糖合成工艺研究[J].江苏工业学院学报,2014,26(4):16-18. |
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| 作者姓名： | 张文楠 黄险峰 宋国强 |
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| 作者单位： | 常州大学制药与生命科学学院,江苏常州,213164 |
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| 摘 要： | 以D-核糖为原料,一步反应制得1-O-甲基-2,3-O-亚异丙基-1-O-甲基-D-呋喃核糖（3）,后经磺酰化、还原、乙酰化反应制得抗癌药物卡培他滨的重要中间体1,2,3-三-O-乙酰基-5-脱氧-D-呋喃核糖（1）,收率73％.
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| 关 键 词： | D-核糖 抗癌药物 1 2 3-三-O-乙酰基-5-脱氧-D-呋喃核糖 |
Study of the Synthesis for 1,2,3-Tri-O-Acetyl-5-Deoxy-D-Ribofuranose |
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| ZHANG Wen-nan,HUANG Xian-feng,SONG Guo-qiang.Study of the Synthesis for 1,2,3-Tri-O-Acetyl-5-Deoxy-D-Ribofuranose[J].Journal of Jiangsu Polytechnic University,2014,26(4):16-18. |
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| Authors: | ZHANG Wen-nan HUANG Xian-feng SONG Guo-qiang |
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| Affiliation: | (School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China) |
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| Abstract: | Starting from D-ribose,1-O-methyl-2,3-O-isopropylidene-D-ribofuranose （3） was prepared by one step.3 was converted into 1,2,3-tri-O-acetyl-5-deoxy-D-ribofuranose（1）,a key intermediate for anti -cancer drug Capecitabine,through esterification,reduction,deprotection and acetylation,and with overall yield of 73%. |
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| Keywords: | D-ribose anti-cancer drug 1 2 3-tri-O-acetyl-5-deoxy-D-ribofuranose |
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