| 小鼠便秘模型的建立 |
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| 引用本文： | 李业鹏,崔生辉,江涛,李燕俊,李玉伟,韩春卉,刘红蕾,张靖. 小鼠便秘模型的建立[J]. 中国食品卫生杂志, 2000, 12(1): 1-4 |
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| 作者姓名： | 李业鹏 崔生辉 江涛 李燕俊 李玉伟 韩春卉 刘红蕾 张靖 |
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| 作者单位： | 卫生部食品卫生监督检验所,北京,100021 |
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| 摘 要： | 为研究保健食品的润肠通便功能,针对保健食品润肠通便功能试验的要求,用１０ｍｇ／ｋｇ ＢＷ的复方地芬诺酯建立了稳定的小鼠便秘模型,模型组与对照组在首粒黑便排便时间、６ｈ内排便粒数及排便重量间均有显性差异（Ｐ〈０．０５）。多次重复实验表明,该模型稳定可靠,建议在保健食品润肠通便功能检测中对其进行验证。
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| 关 键 词： | 保健食品 通便 功能 检测 小鼠便秘模型 实验 |
| 文章编号： | 1004—8456(2000)01—0001—04 |
Development of constipation model of mice |
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| Li Yepeng,Cui Shenghui,Jiang Tao,et al.. Development of constipation model of mice[J]. Chinese Journal of Food Hygiene, 2000, 12(1): 1-4 |
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| Authors: | Li Yepeng Cui Shenghui Jiang Tao et al. |
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| Affiliation: | Li Yepeng,Cui Shenghui,Jiang Tao,et al. Author's address Li Yepeng,Institute of Food Safety Control and Inspection,Ministry of the Public Health of PRC,100021 PRC. |
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| Abstract: | Diphenoxylate wasadministrated to mice by the dose of 10 mg/kg BW for the development of constipation modelfor formulation of examination procedure of health foods. The time of defecation of thefirst black urine, quantity and weight of urine with 6 hours were statisticallysignificant different compared with the control group. The results presented the stabilityand reliability of the model and it was recommended to verify in the function experimentsof health foods. |
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| Keywords: | Diphenoxylate Mice Constipation Dietary Supplements LUBRICANT LAXATION |
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