| 乙醇钠催化合成香豆素-3-羧酸 |
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| 引用本文： | 罗志臣,丁元生. 乙醇钠催化合成香豆素-3-羧酸[J]. 精细石油化工, 2009, 26(4) |
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| 作者姓名： | 罗志臣 丁元生 |
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| 作者单位： | 扬州工业职业技术学院化学工程系,江苏,扬州,225127;吉林化工学院化学与制药工程学院,吉林,吉林,132022 |
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| 摘 要： | 实验以水杨醛、丙二酸二乙酯为原料,乙醇钠为催化剂催化合成香豆素-3-羧酸乙酯,再经皂化、酸解环合合成香豆素-3-羧酸。考察了各种反应条件对香豆素-3-羧酸收率的影响。实验结果表明,其最佳工艺条件为:水杨醛用量4.0 g,n(水杨醛):n(丙二酸二乙酯)=1:1.25,金属钠用量0.25 g、无水乙醇20 mL,反应时间2 h,香豆素3羧酸的收率达到90%以上。
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| 关 键 词： | 乙醇钠 香豆素-3-羧酸乙酯 香豆素-3-羧酸 催化 |
SODIUM ETHOXDE CATALYED SYNTHESIS OF COUMARIN-3-CARBOXYLIC ACID |
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| Luo Zhichen,Ding Yuangsheng. SODIUM ETHOXDE CATALYED SYNTHESIS OF COUMARIN-3-CARBOXYLIC ACID[J]. Speciality Petrochemicals, 2009, 26(4) |
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| Authors: | Luo Zhichen Ding Yuangsheng |
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| Abstract: | Synthesis of coumarin-3-carboxylic acid through sodium ethoxide catalyzed synthesis of cou-marin-3-carboxylic acid ethyl ester, followed by saponification, acidolysis cyclization was studied. The optimum conditions were found as follows: n(diethyl malonate):n(salicylaldehyde) = l:1. 25, 0. 25 g sodium, 20 mL ethanol, 4. 0 g salicylaldehyde and reaction time 2 h. The yield of coumarin -3-car-boxylic acid was above 90%. |
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| Keywords: | sodium ethoxide coumarins-3-carboxylate ethyl ester coumarins-3-carboxylic acid catalytic |
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