改性聚天冬氨酸复合水凝胶的制备及性能

以聚琥珀酰亚胺（PSI）、丙烯酸（AA）和丙烯酰胺（AM）为原料，KH550和KH570为联合交联剂，采用水溶液聚合法合成了聚天冬氨酸/聚（丙烯酸-丙烯酰胺）复合水凝胶［KPAsp/P（AA-AM）］；探讨了交联剂用量、原料配比对KPAsp/P（AA-AM）复合水凝胶溶胀性能的影响；采用FTIR和TG对水凝胶进行了表征。结果表明当v（KH550）∶v（KH570）=1∶1和n（PSI）∶n（AA）∶n（AM）=1∶3∶1时，所合成的复合水凝胶溶胀性能最佳，溶胀度达到395。通过吸水动力学研究表明，共聚链的引入改变了水凝胶的吸水行为。研究了复合水凝胶对阿莫西林的控释性能，结果表明，复合水凝胶的载药量可达29.98mg/g；在37℃、pH=1.8的NaCl溶液中，负载了阿莫西林的复合水凝胶在2h对药物的释放率达到57%，24h左右达到85%。

Preparation and properties of modified polyaspartic acid composite hydrogel

Polyaspartic acid/Poly (acrylic acid-acrylamide) composite hydrogel[KPAsp/P(AA-AM)] were prepared using polysuccinimide (PSI), acrylic acid(AA) and acrylamide(AM) as raw materials and KH550 and KH570 as co-crosslinker by water solution polymerization. The structure of composite hydrogels were characterized by FTIR and TG. The effects of the amount of crosslinker and the ratio of raw materials on the swelling performance of the KPAsp/P(AA-AM) composite hydrogels were investigated. The results showed that the best swelling degree of composite hydrogels is 395, when the feed molar ratio of PSI, AA and AM is 1:3:1 and the volume ratio of KH550 and KH570=1:1. The kinetics of water absorption showed that the addition of copolymer chains changed the water-absorbing behavior of hydrogels. Controlling and releasing properties of Amoxicillin by composite hydrogels were studied.The results showed that the drug loading reached 29.98mg/g. In the solution of NaCl solution (pH=1.8) at 37℃, the release rate of Amoxicillin loaded on composite hydrogel reached 57% and 85% at 2h and 24h, respectively.