| 位阻型硅烷化试剂在药物合成中的研究与应用 |
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| 引用本文： | 邓锋杰,陈萍华,温远庆,蒋华麟. 位阻型硅烷化试剂在药物合成中的研究与应用[J]. 精细化工中间体, 2005, 35(5): 6-9 |
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| 作者姓名： | 邓锋杰 陈萍华 温远庆 蒋华麟 |
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| 作者单位： | 南昌大学,化学系,江西,南昌,330047;南昌航空工业学院,环化系,江西,南昌,330034 |
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| 基金项目： | 江西省自然科学基金资助项目（No 0520038） |
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| 摘 要： | 综述了位阻型硅烷化试剂的特点、保护原理和应用。就其在保护含杂原子的有机官能 团方面讨论了对羟基、羧基、羰基及胺基等的保护和去保护条件及其在药物合成中的应用。并对位 阻型硅烷化试剂的发展趋势进行展望。
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| 关 键 词： | 位阻型 氯硅烷 保护基团 药物合成 选择性 |
| 文章编号： | 1009-9212(2005)05-0006-04 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005-08-15 |
Application of Organosilan as a Protective Reagent in the Synthesis of Pharmaceuticals |
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| DENG Feng-jie,CHEN Ping-hua,WEN Yuan-qing,JIANG Hua-lin. Application of Organosilan as a Protective Reagent in the Synthesis of Pharmaceuticals[J]. Fine Chemical Intermediates, 2005, 35(5): 6-9 |
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| Authors: | DENG Feng-jie CHEN Ping-hua WEN Yuan-qing JIANG Hua-lin |
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| Affiliation: | 1. Department of Chemistry, Nanchang University, Nanchang 330047, China; 2. Department of Enviroment and Chemistry, Nanchang Aviation Industry University, Nanchang 330034, China |
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| Abstract: | The characteristics, protective principle and application of Sterically hindered silane blocking agents were reviewed. Organochlorosilane is widely used in the protection of organic functional groups involving hetero atoms, such as hydroxyl, carboxyl, carbonyl, amino group and so on .The conditions of protection and deprotection and the application development in the synthesis of pharmaceuticals are given in the article. Its trend of development is viewed in this article. |
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| Keywords: | Sterically hindered Organochlorosilane protective group synthesis of pharmaceuticals selective |
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