| 2-氯-4-氨基吡啶的合成 |
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| 引用本文： | 边庆花,乔振,李再锋,李长荣,邢玉芬,王敏. 2-氯-4-氨基吡啶的合成[J]. 化学试剂, 2004, 26(4): 234-236 |
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| 作者姓名： | 边庆花 乔振 李再锋 李长荣 邢玉芬 王敏 |
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| 作者单位： | 中国农业大学,理学院,北京,100094;湛江师范学院,广东,湛江,524048 |
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| 摘 要： | 在对以2—氨基吡啶为原料合成2—氯—4—氨基吡啶的两条路线进行比较的基础上，确定采用乙酰化、氧化、水解、重氮化、氯代、硝化和还原等6步反应的合成路线并通过正交实验得到了最佳的合成工艺，总产率最高可达64．7％，比文献产率提高一倍。
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| 关 键 词： | 2-氯-4-氨基吡啶 合成 |
| 文章编号： | 0258-3283(2004)04-0234-03 |
Synthesis of 2-chloro-4-amino pyridine |
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| BIAN Qing hua,QIAO Zhen,LI Zai feng,LI Chang rong,XING Yu fen,WANG Min. Synthesis of 2-chloro-4-amino pyridine[J]. Chemical Reagents, 2004, 26(4): 234-236 |
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| Authors: | BIAN Qing hua QIAO Zhen LI Zai feng LI Chang rong XING Yu fen WANG Min |
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| Affiliation: | BIAN Qing hua,QIAO Zhen,LI Zai feng,LI Chang rong,XING Yu fen,WANG Min * |
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| Abstract: | Two methods to synthesize 2 chloro 4 amino pyridine were compared to get better conditions.It could be prepared through acetylation,oxidation,hydrolysis,diazotization,chlorination,nitrification and reduction,the general yield was 64.7%(literature,32.2%).The optimum processing conditions were obtained. |
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| Keywords: | chloro-4-amino pyridine synthesis |
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