Modification of biomaterials surface by mimetic cell membrane to improve biocompatibility |
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Authors: | Lei ZHOU, Guo-Xin TAN, Cheng-Yun NING |
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Affiliation: | 1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China2. College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China |
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Abstract: | Modification of biomaterials surface by mimetic cell membrane for improving biocompatibility, to imitate the excellent biological and physiological properties of the natural cell membrane, is an important research area in materials science. Numerous studies have been attempted to construct a mimetic cell membrane biointerface composed of phosphorylcholine (PC)-containing polymers or other phospholipid analogues on biomaterials surface. PC-containing biointerfaces show outstanding characteristics, especially in biological aspects such as blood compatibility and antifouling property. In this mini-review, the strategies of membrane mimetic modification of biomaterials and their antifouling applications are summarized. |
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Keywords: | mimetic cell membrane phosphorylcholine (PC) biocompatibility surfacemodification biomaterial |
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