| 2-芳基苯并咪唑还原水解制备3,5-二甲氧基苯甲醛 |
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| 引用本文： | 徐宝峰. 2-芳基苯并咪唑还原水解制备3,5-二甲氧基苯甲醛[J]. 精细石油化工, 2004, 0(1): 42-44 |
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| 作者姓名： | 徐宝峰 |
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| 作者单位： | 临沂师范学院化学与环境科学系,山东,临沂,276005 |
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| 摘 要： | 报道了白藜芦醇关键中间体 3,5 二甲氧基苯甲醛的合成方法。以苯甲酸为原料 ,经磺化、碱熔、精制得3,5 二羟基苯甲酸 ;再与硫酸二甲酯反应得 3,5 二甲氧基苯甲酸 ,与邻苯二胺反应生成 2 芳基苯并咪唑 ,然后在钠和乙醇及酸作用下还原水解得到 3,5 二甲氧基苯甲醛 ,总收率 2 6 .4 %。
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| 关 键 词： | 3 5-二甲氧基苯甲醛 2-芳基苯并咪唑 还原水解 合成 |
| 修稿时间： | 2002-12-29 |
SYNTHESIS OF 3,5-DIMETHOXYBENZALDEHYDE VIA REDUCTIVE HYDROLYZATION FROM 2-ARYLBENZIMIDAZOL |
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| Xu Baofeng. SYNTHESIS OF 3,5-DIMETHOXYBENZALDEHYDE VIA REDUCTIVE HYDROLYZATION FROM 2-ARYLBENZIMIDAZOL[J]. Speciality Petrochemicals, 2004, 0(1): 42-44 |
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| Authors: | Xu Baofeng |
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| Abstract: | An improved synthetic method of 3,5-dimethoxy benzaldehyde which is the key intermediate for synthesizing resveratrol were studied. With benzoic acid (Ⅰ) as raw material, firstly 3,5-dihydroxybenzoic acid (Ⅱ) was prepared by sulphonation and alkali fusion; then 3,5-dimethoxybenzoic acid (Ⅲ) was synthesized via methylation with dimethyl sulfate; and 2-arylbenzimidazole (Ⅳ) was synthesized from Ⅲ and o-phenylenediamine. After reductive hydrolyzation of Ⅳ with sodium, ethyl alcohol and acid, 3,5-dimethoxy benzaldehyde was obtained with an over all yield of 26.4%. |
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| Keywords: | dimethoxy benzaldehyde 2-arylbenzimidazole reductive hydrolysis synthesis |
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