Chemoenzymatische Synthese von N6-Carbamoyl-D-4-thialysin und N7-Carbamoyl-D-homo-5-thialysin

Chemoenzymatical Synthesis of N⁶-Carbamoyl-D-4-thialysine and N⁷-Carbamoyl-D-homo-5-thialysine The combination of classical chemical and enzymatical methods opens a way to highly functionalized chiral molecules like N⁶-carbamoyl-D-4-thialysine ( 5 ) or N⁷-carbamoyl-D-homo-5-thialysine ( 6 ). The biotransformation of the corresponding hydantoines with Agrobacterium radiobacter is creating the desired D chirality.