Extended Adjuvant Endocrine Treatment in Luminal Breast Cancers in the Era of Genomic Tests |
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Authors: | Mariarosaria Saponaro,Luigi Annunziata,Antonella Turla,Ilaria Viganò ,Michele De Laurentiis,Mario Giuliano,Lucia Del Mastro,Filippo Montemurro,Fabio Puglisi,Carmine De Angelis,Giuseppe Buono,Francesco Schettini,Grazia Arpino |
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Abstract: | In patients with early-stage endocrine receptor-positive (ER+) breast cancer (BC), adjuvant endocrine therapy (ET) for 5 years is the standard of care. However, for some patients, the risk of recurrence remain high for up to 15 years after diagnosis and extended ET beyond 5 years may be a reasonable option. Nevertheless, this strategy significantly increases the occurrence of side effects. Here we summarize the available evidence from randomized clinical trials on the efficacy and safety profile of extended ET and discuss available clinical and genomic tools helpful to select eligible patients in daily clinical practice. |
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Keywords: | late recurrence hormone receptor-positive breast cancer extended endocrine therapy clinical score genomic assays |
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