In vitro biodegradation and biocompatibility of gelatin/montmorillonite-chitosan intercalated nanocomposite |
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Authors: | Hong Zhuang Jun Ping Zheng Hong Gao Kang De Yao |
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Affiliation: | (1) College of Materials Science and Engineering, Tianjin University, Tianjin, 300072, P.R. China |
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Abstract: | The intercalated nanocomposite of gelatin/montmorillonite-chitosan (Gel/MMT-CS) was prepared via the solution intercalation process. In vitro degradation tests showed that the nanocomposite had a lower degradation rate than Gel-CS composite. And the introduced intercalation structure endowed Gel/MMT-CS nanocomposite with a controllable degradation rate when changing the MMT content. Cells attachment, spread and proliferation on the Gel/MMT-CS membranes were investigated by scanning electron microscopy (SEM) and mitochondrial activity assay. The results provided evidences of good adhesion, proliferation and morphology of rat stromal stem cells on Gel/MMT-CS membranes compared to the tissue culture plates (TCPs), making the Gel/MMT-CS nanocomposite a promising candidate towards tissue engineering. |
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