| 生物活性聚乳酸/SiO2-CaO复合薄膜的制备和表征（英文） |
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| 引用本文： | 李晋波,刘宣勇,李伟锋,朱剑豪.生物活性聚乳酸/SiO2-CaO复合薄膜的制备和表征（英文）[J].无机材料学报,2011(9):998-1002. |
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| 作者姓名： | 李晋波 刘宣勇 李伟锋 朱剑豪 |
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| 作者单位： | 湖南大学材料科学与工程学院;中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室;苏州大学材料与化学化工学院;香港城市大学物理与材料科学系; |
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| 基金项目： | Shanghai Science and Technology R&D Fund(1052nm06600); National Natural Science Foundation of China(51071168); Shanghai-Unilever Research and Development Fund(09520715200) |
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| 摘 要： | 以聚乳酸、正硅酸乙酯和硝酸钙为原料,采用溶胶-凝胶方法制备了不同比例的聚乳酸/SiO2-CaO多孔复合薄膜.采用扫描电子显微镜和红外光谱仪对薄膜的微观结构和组成进行分析,并利用表面Zeta电位测定仪对其表面电位进行表征,通过模拟体液浸泡实验和MTT方法对薄膜的生物活性和细胞毒性进行评价.结果表明:复合薄膜在模拟体液中经过7d的浸泡,薄膜表面形成了环状结构的类骨磷灰石层;随着SiO2-CaO含量增加,复合薄膜表面微孔的孔径变小,薄膜表面Zeta电位变负,诱导类骨磷灰石沉积的能力增强;MTT实验证实复合薄膜对MG-63细胞没有毒性且有利于细胞的增殖.
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| 关 键 词： | 聚乳酸 SiO2-CaO Zeta表面电位 生物活性 MTT |
Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO_2-CaO Composite Membranes |
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| LI Jin-Bo,LIU Xuan-Yong,LI Wei-Feng,ZHU Jian-Hao.Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO_2-CaO Composite Membranes[J].Journal of Inorganic Materials,2011(9):998-1002. |
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| Authors: | LI Jin-Bo LIU Xuan-Yong LI Wei-Feng ZHU Jian-Hao |
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| Affiliation: | LI Jin-Bo1,2,LIU Xuan-Yong2,LI Wei-Feng3,ZHU Jian-Hao4(1.College of Materials Science and Engineering,Hunan University,Changsha 410082,China,2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,3.College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,4.Department of Physics & Materials Science,City University of Hong Kong,Hong Kong,China) |
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| Abstract: | A novel porous poly(lactic acid)(PLA)/SiO2-CaO(n(SiO2):n(CaO)=1:1) composite membrane is synthe-sized by Sol-Gel method.The microstructure and composition of the composite membranes are characterized by Fou-rier transform infrared(FTIR) spectroscope and scanning electron microscope(SEM).The surface zeta potential is monitored by the SurPASS electrokinetic analyzer.The bioactivity is evaluated by investigating the formation of apa-tite on the surface of the composite membranes in simulated body fluids and th... |
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| Keywords: | PLA SiO2-CaO Zeta potential bioactivity MTT |
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