Mosaic organization of DNA nucleotides |
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Authors: | CK Peng SV Buldyrev S Havlin M Simons HE Stanley AL Goldberger |
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Affiliation: | Department of Physics, Boston University, Massachusetts 02215, USA. |
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Abstract: | Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations. Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties. |
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