载体材料表面化学组成对蛋白质吸附行为的影响研究进展

蛋白质在载体表面的吸附行为，如其吸附速率、吸附量以及取向和构象的变化，在很大程度上依赖于载体材料的表面化学组成。调控载体材料的表面化学组成已成为控制蛋白质吸附行为的重要手段。本文主要对载体材料表面不同组成对蛋白质吸附行为的影响进行了归纳。介绍了材料表面的功能基团包括疏水基团（甲基和含氟基团）和亲水基团（羟基、氨基和羧基）对蛋白质吸附行为的影响。另外，在载体材料表面接枝聚合物链是一种常用的有效调控表面化学组成的方法。重点介绍了材料表面接枝不同聚合物链时，聚合物链的种类、长度、密度和链的结构对蛋白质吸附行为的影响。

Progress in effect of chemical composition of support surface on the adsorption behavior of protein

The adsorption behavior of protein，such as the rate，amount，and the orientation and conformation variation of protein adsorption，largely depends on the chemical compositions of support surface. Regulation of the chemical composition of support surfaces is one important method to control the adsorption behavior of protein. This paper is mainly to summarize the effects of different chemical composition on protein adsorption behavior. The effects of functional groups，including hydrophobic groups (methyl and fluoride) and hydrophilic groups (hydroxyl，carboxyl and amino)，were presented. In addition，it is one commonly used method to graft polymer chains on the support surfaces. The paper is focused on the species，length，density and shapes of grafted polymer chains on the protein adsorption behavior while grafting diverse polymer chains.